About OICR

OICR is Ontarios cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the biggest challenges in cancer research and deliver real-world solutions to find cancer earlier and treat it more effectively. We are committed to helping people living with cancer, as well as future generations, live longer and healthier lives.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through theMinistry ofColleges, Universities, Research Excellence and Security.

Job Details

Position: Postdoctoral Fellow

Location: MaRS Centre, Toronto

Department: Drug Discovery

Reports To: Senior Scientific Advisor

Salary: Commensurate with level of experience; total compensation includes a competitive benefits plan, plus a defined benefit pension plan (HOOPP)

Hours: 35hours/week

Job Type: On-site

Status: Full-time, temporary for one (1) year with potential to renew for one (1) year

Position Summary

The Ontario Institute for Cancer Research (OICR) is seeking a talented Postdoctoral Fellow to participate in projects with the aim of discovery of potent small molecule modulators of drug target function towards development of therapeutics for various cancers. These projects include protein production and characterization, biophysical and biochemical assays, small molecule screening, and other related in vitro drug discovery processes in Prof. Masoud Vedadis lab at OICR in a team work environment. The target proteins include protein complexes and protein-protein interactions, protein degradation and DNA repair pathways. A few examples of the most recent publications from Vedadis lab are: PMIDs: 39580491, 36948210, 37749144, 37728236, 38104184.

This position is temporary, full-time for one (1) year with potential to renew for one (1) year.

Position Responsibilities

• Protein production and purification
• Biophysical and biochemical characterization of cancer drug targets
• Development of assays and optimization for high-throughput screening
• Employ various screening methods towards discovery of small molecule modulators of the function of the drug targets
• Work within a teamwork environment towards potent, selective and cell active small molecules for drug discovery
• Maintain meticulous records of experimental procedures and data
• Liaise effectively with multi-disciplinary team members (computational chemistry, medicinal chemistry, and ADME groups) within the Drug Discovery Program, with other OICR Research Programs, and with academic and industry collaborators
• Participate in team meetings, both internal and external
• Present results to internal and external audiences, and contribute to funding applications, as well as manuscripts for peer-reviewed journals
• Work effectively under pressure and tight timelines
• Adhere to all OICR safety guidelines and policies, strongly advocates safety to others
  

Qualifications

• Completion of a PhD degree within the last 5 years
• Experience in protein production
• Strong knowledge in protein biochemistry with significant experience in enzymology, binding assays, and protein biochemical and biophysical characterization
• Experience working with E3 ligases, and/or protein-protein interaction studies
• Excellent publication record
• Excellent communication and organizational skills
• Some exposure in small molecule screening and/or working with targeted families of proteins described above
  

For more information about OICR, please visit the website at www.oicr.on.ca.

To learn more about working at OICR, visit our career page.

POSTED DATE: April 29, 2025
CLOSING DATE: Until Filled

OICR is committed to fostering a climate of equity, diversity, inclusion, and accessibility. This commitment is central to, and mutually supportive of, our research excellence mandate. We welcome and respect the diversity of all members of our community and we support an inclusive culture for all. We welcome all applicants, and encourage applications from racialized persons, Indigenous Peoples, women, persons with disabilities, LGBTQ2S persons, and others who may contribute to furthering a diversity of ideas within our community. OICR is committed to fair assessment of a candidates abilities, and consideration for diversity of thought, method, and experience. Providing an accessible workplace and recruitment process is important to us, as described in our Accessibility Plan (https://oicr.on.ca/accessibility/). Should you require accommodation during any stage in the recruitment process, please complete the form at the bottom of page https://oicr.on.ca/careers/. Information received related to accommodation will be handled confidentially.

Resume Format:If you elect to apply, please click on the Apply for this Job button below. You will be required to enter contact details, and to attach your resume to your application.Please attach your resume as a .pdf or .doc file.

The Ontario Institute for Cancer Research thanks all applicants. However, only those under consideration will be contacted.